On Tuesday, April 10, at 13:00,Sebastian Bauer, Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt will speak in the NeuroBioTheory seminar series in the Giersch Science Center seminar room 007/008 (sister building of FIAS) on the Riedberg Campus of Goethe University.
Title: Mesial temporal lobe epilepsy – is there a link between hippocampal cytokine release and EEG features?
Joint work with: Valentin Neubert 1,2, Kai Siebenbrodt 1,2, Florian Schertz 3, Felix Rosenow 1,2
1 Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt
2 Philipps-University Marburg
3 Surface Concept GmbH, Mainz
Background: Epilepsies affect >50 million people worldwide. Mesial temporal lobe (mTLE) with hippocampal sclerosis (HS) is one of the most common forms of focal epilepsies. The transformation of the normal hippocampal architecture into epileptogenic tissue (epileptogenesis) is associated with mechanisms of innate immunity, in particular with the action of pro- and anti-inflammatory cytokines. In addition, cytokines can directly modulate neuronal excitability.