Priv.-Doz. Dr. Angela Brieger

Kontakt:

Telefon: +49 69 6301 6218

E-Mail: a.brieger@em.uni-frankfurt.de 

 

Adresse:

Universitätsklinikum Frankfurt

Medizinische Klinik 1

Biomedizinisches Forschungslabor

Haus 11, 2.OG, Zimmer 224

Theodor-Stern-Kai 7

60590 Frankfurt

 

Forschungsgruppe:

·           hier klicken

 

 

 

Publications – PD Dr. Angela Brieger

Hinrichsen I, Ackermann A, Düding T, Graband A, Filmann N, Plotz G, Zeuzem S and Brieger A. Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648. Mol Carcinog. accepted 2017 Feb.

Adam R, Spier I, Zhao B, Kloth M, Marquez J, Hinrichsen I, Kirfel J, Tafazzoli A, Horpaopan S, Uhlhaas S, Stienen D, Friedrichs N, Altmüller J, Laner A, Holzapfel S, Peters S, Kayser K, Thiele H, Holinski-Feder E, Marra G, Kristiansen G, Nöthen MM, Büttner R, Möslein G, Betz RC, Brieger A, Lifton RP, Aretz S. Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. Am J Hum Genet. 2016 Aug 4;99(2):337-51.

 

Hinrichsen I, Schäfer D, Langer D, Köger N, Wittmann M, Aretz S, Steinke V, Holzapfel S, Trojan J, König R, Zeuzem S, Brieger A, Plotz G. Functional testing strategy for coding genetic variants of unclear significance in MLH1 in Lynch syndrome diagnosis. Carcinogenesis. 2015 Feb;36(2):202-11.

 

Hinrichsen I, Ernst BP, Nuber F, Passmann S, Schäfer D, Steinke V, Friedrichs N, Plotz G, Zeuzem S, Brieger AReduced migration of MLH1 deficient colon cancer cells depends on SPTAN1. Mol Cancer. 2014 Jan 24;13:11

 

Hinrichsen I, Kemp M, Peveling-Oberhag J, Passmann S, Plotz G, Zeuzem S, Brieger APromoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs. PLoS One. 2014 Jan 6;9(1):e84453.

 

Borràs E, Pineda M, Cadiñanos J, Del Valle J, Brieger A, Hinrichsen I, Cabanillas R, Navarro M, Brunet J, Sanjuan X, Musulen E, van der Klift H, Lázaro C, Plotz G, Blanco I, Capellá G. Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants. J Med Genet. 2013 Aug;50(8):552-63.

 

Hinrichsen I, Brieger A, Trojan J, Zeuzem S, Nilbert M, Plotz G. Expression defect size among unclassified MLH1 variants determines pathogenicity in Lynch syndrome diagnosis. Clin Cancer Res. 2013 May 1;19(9):2432-41

 

Borràs E, Pineda M, Brieger A, Hinrichsen I, Gómez C, Navarro M, Balmaña J, Ramón y Cajal T, Torres A, Brunet J, Blanco I, Plotz G, Lázaro C, Capellá G. Comprehensive functional assessment of MLH1 variants of unknown significance. Hum Mutat. 2012 Nov;33(11):1576-88. Erratum in: Hum Mutat. 2013 Jan;34(1):274.

 

Plotz G, Casper M, Raedle J, Hinrichsen I, Heckel V, Brieger A, Trojan J, Zeuzem S. MUTYH gene expression and alternative splicing in controls and polyposis patients. Hum Mutat. 2012 Jul;33(7):1067-74.

 

Brieger A, Plotz G, Hinrichsen I, Passmann S, Adam R, Zeuzem S. C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins. PLoS One. 2012;7(2):e31863

 

Brieger A, Engels K, Schaefer D, Plotz G, Zeuzem S, Raedle J, Trojan J. Malignant fibrous histiocytoma is a rare Lynch syndrome-associated tumor in two German families. Fam Cancer. 2011 Sep;10(3):591-5.

 

Brieger A, Adam R, Passmann S, Plotz G, Zeuzem S, Trojan J. A CRM1-dependent nuclear export pathway is involved in the regulation of MutLα subcellular localization. Genes Chromosomes Cancer. 2011 Feb;50(2):59-70.

 

Brieger A, Adryan B, Wolpert F, Passmann S, Zeuzem S, Trojan J. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. Proteomics. 2010 Sep;10(18):3343-55.

 

Meyer C, Brieger A, Plotz G, Weber N, Passmann S, Dingermann T, Zeuzem S, Trojan J, Marschalek R. An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family. Clin Cancer Res. 2009 Feb 1;15(3):762-9.

 

Brieger A, Plotz G, Zeuzem S, Trojan J. Thymosin beta 4 expression and nuclear transport are regulated by hMLH1. Biochem Biophys Res Commun. 2007 Dec 28;364(4):731-6.

 

Brieger A, Plotz G, Raedle J, Weber N, Baum W, Caspary WF, Zeuzem S, Trojan J. Characterization of the nuclear import of human MutLalpha. Mol Carcinog. 2005 May;43(1):51-8.

 

Trojan J, Brieger A, Raedle J, Weber N, Kriener S, Kronenberger B, Caspary WF, Zeuzem S. BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability. Int J Colorectal Dis. 2004 Nov;19(6):538-44.

 

Brieger A, Boehrer S, Schaaf S, Nowak D, Ruthardt M, Kim SZ, Atadja P, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. Biochem Pharmacol. 2004 Jul 1;68(1):85-93.

 

Boehrer S, Brieger A, Schaaf S, Kukoc-Zivojnov N, Nowak D, Ruthardt M, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. Leuk Lymphoma. 2004 Jul;45(7):1445-51.

 

Nowak D, Boehrer S, Brieger A, Kim SZ, Schaaf S, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus. Leuk Lymphoma. 2004 Jul;45(7):1429-36.

 

Caluseriu O, Di Gregorio C, Lucci-Cordisco E, Santarosa M, Trojan J, Brieger A, Benatti P, Pedroni M, Colibazzi T, Bellacosa A, Neri G, Ponz de Leon M, Viel A, Genuardi M. A founder MLH1 mutation in families from the districts of Modena and Reggio-Emilia in northern Italy with hereditary non-polyposis colorectal cancer associated with protein elongation and instability. J Med Genet. 2004 Mar;41(3):e34.

 

Boehrer S, Nowak D, Schaaf S, Bergmann M, Brieger A, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. In malignant myeloid cells expression of Daxx downregulates expression of p53 and of the inhibitors of apoptosis proteins. Hematol J. 2004;5(6):513-8.

 

Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S. N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha. Nucleic Acids Res. 2003 Jun 15;31(12):3217-26.

 

Brieger A, Trojan J, Raedle J, Plotz G, Zeuzem S. Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants. Gut. 2002 Nov;51(5):677-84.

 

Raedle J, Schaffner M, Esser N, Sahm S, Trojan J, Kriener S, Brieger A, Nier H, Bockhorn H, Berg PL, Frick B, Schäfer D, Zeuzem S. Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer. Z Gastroenterol. 2002 Aug;40(8):561-8.

 

Trojan J, Raedle J, Herrmann G, Brieger A, Zeuzem S. Detection of microsatellite instability from archival, hematoxylin-eosin-stained colorectal cancer specimen. Arch Pathol Lab Med. 2002 Feb;126(2):202-4.

 

Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S. hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 2002 Feb 1;30(3):711-8.

 

Trojan J, Zeuzem S, Randolph A, Hemmerle C, Brieger A, Raedle J, Plotz G, Jiricny J, Marra G. Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology. 2002 Jan;122(1):211-9.

 

Trojan J, Plotz G, Brieger A, Raedle J, Meltzer SJ, Wolter M, Zeuzem S. Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease. J Invest Dermatol. 2001 Dec;117(6):1650-3.

 

Raedle J, Trojan J, Brieger A, Weber N, Schäfer D, Plotz G, Staib-Sebler E, Kriener S, Lorenz M, Zeuzem S. Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer. Ann Intern Med. 2001 Oct 16;135(8 Pt 1):566-76.

 

Trojan J, Brieger A, Raedle J, Esteller M, Zeuzem S. 5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. Gut. 2000 Aug;47(2):272-6.

 

Brieger A, Trojan J, Raedle J, Roth WK, Zeuzem S. Identification of germline mutations in hereditary nonpolyposis colorectal cancer