Publikationen 2019

  1. Zucker M, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M. LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension. Biochim Biophys Acta - Mol Basis Dis, 1865:1604-1616, 2019

  2. Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LTH, Brandts C, Fulda S, Wygrecka M, and Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol., 77, 4-22, 2019

  3. Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Muench C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L: Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury.  Kidney Int., 95: 540-562, 2019

  4. Christen U. Pathogen infection and autoimmune disease. Clin Exp Immunol., 195(1): 10-14, 2019

  5. Christen U and Hintermann E. Pathogens and autoimmune hepatitis. Clin Exp Immunol., 195(1): 35-51, 2019

  6. Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Cell, 176(6): 1407-1419, 2019

  7. Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J., 33(2): 1711-1726, 2019

  8. Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids, 1864(3): 304-311, 2019

  9. Violatto MB, Casarin E, Talamini L, Russo L, Baldan S, Tondello C, Messmer M, Hintermann E, Rossi A, Passoni A, Bagnati R, Biffi S, Toffanin C, Gimondi S, Fumagalli S, De Simoni MG, Barisani D, Salmona M, Christen U, Invernizzi P, Bigini P, Morpurgo M. Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model. ACS Nano, 13(4): 4410-4423, 2019

  10. Roedig H, Nastase MV, Wygrecka M, Schaefer L. Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J., 286(15): 2965-2979, 2019

  11. Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene, 38(24): 4788-4803, 2019

  12. Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S. Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. Nitric Oxide, 87: 31-42, 2019

  13. Büttner S, Koch A, Pfeilschifter J. Diuretic Therapy. Dtsch Med Wochenschr., 144(6): 387-392, German, 2019

  14. Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M. Lipids - two sides of the same coin in lung fibrosis.Cell Signal, 60: 65-80, 2019

  15. Christen U. Animal models of autoimmune hepatitis. Biochim Biophys Acta- Mol Bases Dis, 1865(5): 970-981, 2019

  16. Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol., 186: 130-135, 2019

  17. Didiasova M, Schaefer L, Wygrecka M. When place matters: shuttling of enolase-1 across cellular compartments.Front Cell Dev Biol., 26;7:61. doi: 10.3389/fcell.2019.00061. eCollection 2019.

  18. von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic  M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B. Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis. Theranostics, 16;9(7): 2003-2016, 2019

  19. Fuchs S, Bayer M, Taubert R, Manns MP, Pfeilschifter JM, Christen U, Hintermann E. Effects of adenovirus-induced hepatocyte damage on chronic bileduct inflammation in a sclerosing cholangitis mouse model.Liver Int. 2019 Jun 21. doi: 10.1111/liv.14183. [Epub ahead of print] PubMed PMID: 31225929.

  20. Mücke VT, Thomas D, Mücke MM, Waidmann O, Zeuzem S, Sarrazin C, Pfeilschifter J, Vermehren J, Finkelmeier F, Grammatikos G. Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response. Liver Int. 2019 Jun 17. doi: 10.1111/liv.14178. [Epub ahead of print] PubMed PMID: 31207039.

  21. Patyna S, Büttner S, Eckes T, Obermüller N, Bartel C, Braner A, Trautmann S, Thomas D, Geiger H, Pfeilschifter J, Koch A. Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus. Prostaglandins Other Lipid Mediat. 2019 Jul 10:106348. doi: 10.1016/j.prostaglandins.2019.106348. [Epub ahead of print] PubMed PMID: 31301404.

  22. Eberhardt W, Nasrullah U and Haeussler K. Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?Cells, 8, 797, 2019

  23. Mühl H, Bachmann M. IL-18/IL-18BP and IL-22/IL-22BP:Two interrelated couples with therapeutic potential.Cell Signal., Aug 8:109388. doi: 10.1016/j.cellsig.2019.109388. [Epub ahead of print], 2019

  24. Roedig H, Damiescu R, Zeng-Brouwers J, Kutija I, Trebicka J, Wygrecka M, Schaefer L. Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development. Semin Cancer Biol doi: 10.1016/j.semcancer.2019.07.026, 2019 (in press)

  25. Ghițu A, Schwiebs A, Radeke HH, Avram S, Zupko I, Bor A, Pavel IZ, DeheleanCA, Oprean C, Bojin F, Farcas C, Soica C, Duicu O, Danciu C. A ComprehensiveAssessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound. Nutrients, 16;11(4), 2019

  26. Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, Fuhrmann D, Petcherski A, Heringdorf DMZ, Radeke HH, Brüne B. Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation. Biochim Biophys Acta - Mol Cell Biol Lipids, 1864(9): 1235-1246, 2019

  27. Danciu C, Pinzaru I, Coricovac D, Andrica F, Sizemore I, Dehelean C, Baderca F, Lazureanu V, Soica C, Mioc M, Radeke H. Betulin silver nanoparticles qualify as efficient antimelanoma agents in in vitro and in vivo studies. Eur J Pharm Biopharm., 134: 1-19, 2019

  28. Dreis C, Ottenlinger FM, Putyrski M, Ernst A, Huhn M, Schmidt KG, Pfeilschifter JM, Radeke HH. Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T  Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs. Front Immunol., 10: 1698, 2019

  29. Hewitt SM, Schaefer L. Renal Fibrosis: Common Enemy of Many Origins. J Histochem Cytochem., 67(9): 621, 2019

Publikationen 2018

  1. Nastase MV, Janicova A, Roedig H, Hsieh LTH, Wygrecka M, and Schaefer L. Small leucine-rich proteoglycans in renal inflammation: two sides of the coin. J Histochem Cytochem, 66(4): 261-272, 2018

  2. Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, and Schaefer L. Danger associated molecular patterns from the extracellular matrix provide temporal control of innate immunity. J Histochem Cytochem, 66(4): 213–227, 2018

  3. Wujak L, Böttcher R, Pak O, Frey H, El Agha E, Chen Y, Schmitt S, Bellusci S, Schaefer L, Weissmann N, Fässler R, and Wygrecka M. Low Density Lipoprotein Receptor-related Protein 1 Couples β1 Integrin Activation to Degradation.Cell Mol Life Sci, 75: 1671-1685, 2018

  4. Hermann A, Wennmann DO, Gromnitza S, Edeling M, van Marck V, Sudol M, Schaefer L, Duning K, Weide T, Pavenstädt H, and Kremerskother J. WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hepatology, 67(4): 1546-1559, 2018

  5. Hardt S, Valek L, Zeng-Brouwers J, Wilken-Schmitz A, Schaefer L, and Tegeder I. Nephrogenic diabetes insipidus in aged progranulin deficient mice. Aging Dis. 9(5): 817-830, 2018

  6. Vutukuri R, Brunkhorst R, Kestner RI, Hansen L, Ferreiros Bouzas N, Pfeilschifter J, Devraj K, and Pfeilschifter W.Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption. J Neurochem., 144(2): 172-185, 2018

  7. Schwiebs A and Radeke H. Immunopharmacological activity of betulin in inflammation-associated carcinogenesis.Anticancer Agents Med Chem. 18(5): 645-651, 2018

  8. Wujak L, Schnieder J, Schaefer L, and Wygrecka M. LRP1: a chameleon receptor of lung inflammation and repair.Matrix Biol., 68-69: 366-381, 2018

  9. Imre G and Rajalingam K. Apoptosis Inhibitor 5: Role in the inhibition of caspase-2. Cell Cycle. 17(4): 397-398, 2018

  10. Nastase MV, Zeng-Brouwers J, Wygrecka M, and Schaefer L. Targeting renal fibrosis: mechanisms and drug delivery systems. Adv Drug Deliv Rev, 129: 295-307, 2018

  11. Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Hattenbach LO, Pfeilschifter J, and Pfeilschifter W. Sphingosine kinase 2 modulates retinal neovascularization Invest Ophthalmol Vis Sci., 59(2): 653-661, 2018

  12. Bachmann M, Pfeilschifter J, and Mühl H. A prominent role of IL-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation. Front Immunol, 9: 161. doi: 10.3389/fimmu.2018.00161. eCollection 2018

  13. Goren I, Christen U, Pfeilschifter J, and Stefan Frank. A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds. Nitric Oxide, 74:23-31, 2018

  14. Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M, and Schaefer L.Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biol 68-69: 293-317, 2018

  15. Bachmann M, Pfeilschifter J, and Mühl H. Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells. BBA-GENE REGUL MECH, 1861(3): 191-199, 2018

  16. Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, and Wygrecka M. Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta - Molecular Basis of Disease, 1864(5 Pt A): 1816-1827, 2018

  17. Wagner J, Chavakis E, Rogg E-M, Muhly-Reinholz M, Glaser SF, Guenther S, John D, Bonini F, Zeiher A, Schaefer L, Hannocks M-J, Boon RA, and Dimmeler S. A switch in laminin β2 to laminin β1 isoforms during aging enhances endothelial-mesenchymal transition. Arterioscler Thromb Vasc Biol., 38: 1170-1177, 2018

  18. Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, and Eberhardt W. Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells. Oncotarget, 9(26): 18367-18385, 2018

  19. Didiasova M, Schaefer L, and Wygrecka M. Targeting GLI transcription factors in cancer.  Molecules, 23(5). pii: E1003. doi: 10.3390/molecules23051003, 2018

  20. Schaefer L. Decoding fibrosis: Mechanisms and translational aspects. Matrix Biol 68-69: 1-7, 2018

  21. Brunkhorst R, Pfeilschifter W, Patyna S, Büttner S, Eckes T, Trautmann S, Thomas D, Pfeilschifter J, and Koch A.Preanalytical Biases in the Measurement of Human Blood Sphingolipids. Int J Mol Sci., 19(5), 2018

  22. Patyna S, Eckes T, Büttner S, Pfeilschifter J, and Koch A. Sphingosine 1-phosphate in renal diseases: Molecular mechanisms and clinical relevance. Nieren- und Hochdruckkrankheiten, Jahrgang 47, März (137-141), 2018

  23. Huwiler A and Pfeilschifter J. Sphingolipid signaling in renal fibrosis. Matrix Biol., 68-69, 230-247, 2018

  24. Christen U, Hintermann E. Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease? Front Immunol. 2018 Feb 16;9:163. doi: 10.3389/fimmu.2018.00163. eCollection 2018. Review.

  25. Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, and Christen U. Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun., 91: 83-96, 2018

  26. Kwapiszewska G, Gungl A, Wilhelm J, Marsh L, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, and Wygrecka M. Transcriptome profiling reveals the complexity of pirfenidone effects in IPF.  Eur Respir J, 52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018, 2018

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