Publikationen 2019

  1. Zucker M, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M. LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension. Biochim Biophys Acta Mol Basis Dis, 1865:1604-1616, 2019

  2. Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LTH, Brandts C, Fulda S, Wygrecka M, and Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol., 77, 4-22, 2019

  3. Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Muench C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L: Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury.Kidney Int., 95: 540-562, 2019

  4. Christen U and Hintermann E. Pathogens and autoimmune hepatitis. Clin Exp Immunol., 195(1): 35-51, 2019

  5. Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J. 2019 Feb;33(2):1711-1726.

  6. Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids, 1864(3): 304-311, 2019

  7. Roedig H, Nastase MV, Wygrecka M, Schaefer L. Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J. 2019 Feb 18. doi: 10.1111/febs.14791. [Epub ahead of print] PubMed PMID: 30776184.

  8. Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene. doi: 10.1038/s41388-019-0758-x. [Epub ahead of print] PubMed PMID: 30816345,2019 (in press)

  9. Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S. Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. Nitric Oxide,87: 31-42, 2019

  10. Büttner S, Koch A, Pfeilschifter J. Diuretic Therapy. Dtsch Med Wochenschr., 144(6): 387-392, German, 2019

  11. Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M. Lipids - two sides of the same coin in lung fibrosis.Cell Signal, 60: 65-80, 2019

  12. Christen U. Animal models of autoimmune hepatitis. Biochim Biophys Acta- Mol Bases Dis, 1865(5):970-981, 2019

  13. Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol., 186:130-135, 2019

  14. Didiasova M, Schaefer L, Wygrecka M. When place matters: shuttling of enolase-1 across cellular compartments.Front Cell Dev Biol., 26;7:61. doi: 10.3389/fcell.2019.00061. eCollection 2019.

  15. Patyna S, Büttner S, Eckes T, Obermüller N, Bartel C, Braner A, Trautmann S, Thomas D, Geiger H, Pfeilschifter J, Koch A. Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus. Prostaglandins Other Lipid Mediat. 2019 Jul 10:106348. doi: 10.1016/j.prostaglandins.2019.106348. [Epub ahead of print] PubMed PMID: 31301404.

  16. Eberhardt W, Nasrullah U and Haeussler K. Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?Cells, 8, 797, 2019

  17. Mühl H, Bachmann M. IL-18/IL-18BP and IL-22/IL-22BP:Two interrelated couples with therapeutic potential.Cell Signal., Aug 8:109388. doi: 10.1016/j.cellsig.2019.109388. [Epub ahead of print], 2019

  18. Roedig H, Damiescu R, Zeng-Brouwers J, Kutija I, Trebicka J, Wygrecka M, Schaefer L. Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development. Semin Cancer Biol doi: 10.1016/j.semcancer.2019.07.026, 2019 (in press)

Publikationen 2018

  1. Nastase MV, Janicova A, Roedig H, Hsieh LTH, Wygrecka M, and Schaefer L. Small leucine-rich proteoglycans in renal inflammation: two sides of the coin. J Histochem Cytochem, 66(4): 261-272, 2018

  2. Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, and Schaefer L. Danger associated molecular patterns from the extracellular matrix provide temporal control of innate immunity. J Histochem Cytochem, 66(4): 213–227, 2018

  3. Wujak L, Böttcher R, Pak O, Frey H, El Agha E, Chen Y, Schmitt S, Bellusci S, Schaefer L, Weissmann N, Fässler R, and Wygrecka M. Low Density Lipoprotein Receptor-related Protein 1 Couples β1 Integrin Activation to Degradation.Cell Mol Life Sci, 75: 1671-1685, 2018

  4. Hermann A, Wennmann DO, Gromnitza S, Edeling M, van Marck V, Sudol M, Schaefer L, Duning K, Weide T, Pavenstädt H, and Kremerskother J. WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hepatology, 67(4): 1546-1559, 2018

  5. Hardt S, Valek L, Zeng-Brouwers J, Wilken-Schmitz A, Schaefer L, and Tegeder I. Nephrogenic diabetes insipidus in aged progranulin deficient mice. Aging Dis. 9(5): 817-830, 2018

  6. Vutukuri R, Brunkhorst R, Kestner RI, Hansen L, Ferreiros Bouzas N, Pfeilschifter J, Devraj K, and Pfeilschifter W.Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption. J Neurochem., 144(2): 172-185, 2018

  7. Schwiebs A and Radeke H. Immunopharmacological activity of betulin in inflammation-associated carcinogenesis.Anticancer Agents Med Chem. 18(5): 645-651, 2018

  8. Wujak L, Schnieder J, Schaefer L, and Wygrecka M. LRP1: a chameleon receptor of lung inflammation and repair.Matrix Biol., 68-69: 366-381, 2018

  9. Imre G and Rajalingam K. Apoptosis Inhibitor 5: Role in the inhibition of caspase-2. Cell Cycle. 17(4): 397-398, 2018

  10. Nastase MV, Zeng-Brouwers J, Wygrecka M, and Schaefer L. Targeting renal fibrosis: mechanisms and drug delivery systems. Adv Drug Deliv Rev, 129: 295-307, 2018

  11. Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Hattenbach LO, Pfeilschifter J, and Pfeilschifter W. Sphingosine kinase 2 modulates retinal neovascularization Invest Ophthalmol Vis Sci., 59(2): 653-661, 2018

  12. Bachmann M, Pfeilschifter J, and Mühl H. A prominent role of IL-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation. Front Immunol, 9: 161. doi: 10.3389/fimmu.2018.00161. eCollection 2018

  13. Goren I, Christen U, Pfeilschifter J, and Stefan Frank. A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds. Nitric Oxide, 74:23-31, 2018

  14. Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M, and Schaefer L.Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biol 68-69: 293-317, 2018

  15. Bachmann M, Pfeilschifter J, and Mühl H. Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells. BBA-GENE REGUL MECH, 1861(3): 191-199, 2018

  16. Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, and Wygrecka M. Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta - Molecular Basis of Disease, 1864(5 Pt A): 1816-1827, 2018

  17. Wagner J, Chavakis E, Rogg E-M, Muhly-Reinholz M, Glaser SF, Guenther S, John D, Bonini F, Zeiher A, Schaefer L, Hannocks M-J, Boon RA, and Dimmeler S. A switch in laminin β2 to laminin β1 isoforms during aging enhances endothelial-mesenchymal transition. Arterioscler Thromb Vasc Biol., 38: 1170-1177, 2018

  18. Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, and Eberhardt W. Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells. Oncotarget, 9(26): 18367-18385, 2018

  19. Didiasova M, Schaefer L, and Wygrecka M. Targeting GLI transcription factors in cancer.  Molecules, 23(5). pii: E1003. doi: 10.3390/molecules23051003, 2018

  20. Schaefer L. Decoding fibrosis: Mechanisms and translational aspects. Matrix Biol 68-69: 1-7, 2018

  21. Brunkhorst R, Pfeilschifter W, Patyna S, Büttner S, Eckes T, Trautmann S, Thomas D, Pfeilschifter J, and Koch A.Preanalytical Biases in the Measurement of Human Blood Sphingolipids. Int J Mol Sci., 19(5), 2018

  22. Patyna S, Eckes T, Büttner S, Pfeilschifter J, and Koch A. Sphingosine 1-phosphate in renal diseases: Molecular mechanisms and clinical relevance. Nieren- und Hochdruckkrankheiten, Jahrgang 47, März (137-141), 2018

  23. Huwiler A and Pfeilschifter J. Sphingolipid signaling in renal fibrosis. Matrix Biol., 68-69, 230-247, 2018

  24. Christen U, Hintermann E. Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease? Front Immunol. 2018 Feb 16;9:163. doi: 10.3389/fimmu.2018.00163. eCollection 2018. Review.

  25. Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, and Christen U. Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun., 91: 83-96, 2018

  26. Kwapiszewska G, Gungl A, Wilhelm J, Marsh L, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, and Wygrecka M. Transcriptome profiling reveals the complexity of pirfenidone effects in IPF.  Eur Respir J, 52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018, 2018

  27. Rogg EM, Abplanalp WT, Bischof C, John D, Schulz MH, Krishnan J, Fischer A, Poluzzi C, Schaefer L, Bonauer A, Zeiher AM, and Dimmeler S. Analysis of cell type-specific effects of miR-92a provides novel insights into target regulation and mechanism of action. Circulation, 138:2545-2558, 2018

  28. Didiasova M, Wujak M, Schaefer L, Wygrecka M: Cellular effects of coagulation factor XII. Cell Signal, 51: 257-265. 2018

  29. Beyer S, Schwalm S, Pfeilschifter J, and Huwiler A. Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis. Cell Physiol Biochem., 47: 2522-2533, 2018

  30. Eberhardt W, Nasrullah U, and Pfeilschifter J. Activation of renal profibrotic TGFbeta controlled signaling cascades by calcineurin and mTOR inhibitors. Cell Signal, 52: 1-11, 2018

  31. Luger S, Schwebler A, Vutukuri R, Bouzas NF, Labocha S, Schreiber Y, Brunkhorst R, Steinmetz H, Pfeilschifter J, Pfeilschifter W. Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke. Ther Adv Neurol Disord., 2018 Apr 19;11:1756286418769830. doi: 10.1177/1756286418769830. eCollection 2018

  32. Danciu C, Zupko I, Bor A, Schwiebs A, Radeke H, Hancianu M, Cioanca O, Alexa E, Oprean C, Bojin F, Soica C, Paunescu V, and Dehelean CA. Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells.Int J Mol Sci., 19(11). pii: E3624, 2018

  33. Blanchard O, Stepanovska B, Starck M, Erhardt M, Römer I, Meyer Zu Heringdorf D, Pfeilschifter J, Zangemeister-Wittke U, Huwiler A. Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells. Int J Mol Sci., 19(5). pii: E1498, 2018

  34. Bruno G, Cencetti F, Bernacchioni C, Donati C, Blankenbach KV, Thomas D, Meyer Zu Heringdorf D, Bruni P. Bradykinin mediates myogenic differentiation in murine myoblasts through the involvement of SK1/Spns2/S1P(2) axis. Cell Signal., 45: 110-121, 2018

  35. Josipovic I, Pflüger B, Fork C, Vasconez AE, Oo JA, Hitzel J, Seredinski S, Gamen E, Heringdorf DMZ, Chen W, Looso M, Pullamsetti SS, Brandes RP, Leisegang MS. Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell  function. J Mol Cell Cardiol., 116: 57-68, 2018

  36. Pleli T, Mondorf A, Ferreiros N, Thomas D, Dvorak K, Biondi RM, Heringdorf DMZ, Zeuzem S, Geisslinger G, Zimmermann H, Waidmann O, Piiper A. Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors. Cell Physiol Biochem., 45(6): 2516-2528, 2018

  37. Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D. Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses. Biochim Biophys Acta Mol Cell Biol Lipids., 1863(4): 433-446, 2018

  38. Moll F, Walter M, Rezende F, Helfinger V, Vasconez E, De Oliveira T, Greten FR, Olesch C, Weigert A, Radeke HH, Schröder K. NoxO1 Controls Proliferation of Colon Epithelial Cells. Front Immunol., 9:973. doi: 10.3389/fimmu.2018.00973. eCollection 2018, 2018 

Publikationen 2017

  1. Goren I, Lee SY, Maucher D, Nüsing R, Schlich T, Pfeilschifter J, and Frank S. Inhibition of cyclooxygenase-1 and -2 activity in keratinocytes inhibits PGE2 formation and impairs VEGF release and neovascularization in skin wounds.Int Wound J., 14: 53-63, 2017

  2. Frey H, Moreth K, Hsieh LTH, Zeng-Brouwers J, Rathkolb B, Fuchs H, Gailus-Durner V, Iozzo RV, Hrabě de Angelis M, and Schaefer L. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J., 34(3): 393-404, 2017

  3. Schaefer L, Tredup C, Gubbiotti M, and Iozzo RV. Proteoglycan neofunctions: Regulation of inflammation and autophagy in cancer biology. FEBS J 284: 10-26, 2017

  4. Bender C, Christen S, Scholich K, Bayer M, Pfeilschifter JM, Hintermann E, and Christen U. Islet-expressed CXCL10 Promotes Autoimmune Destruction of Islet Iso-Grafts in Mice with Type 1 Diabetes. Diabetes. 66(1): 113-126, 2017

  5. Didiasova M, Singh R, Kwapiszewska G, Wujak L, Zakrzewicz D, Markart P, Seeger W, Schaefer L, Lauth M, and Wygrecka M. Pirfenidone exerts anti-fibrotic effects through a direct inhibition of GLI transcription factors. FASEB J 31: 1916-1928, 2017

  6. Martin J, Radeke HH, Dignass A and Stein J. Curent evaluation and management of anaemia in patients with inflammatory bowel disease. Expert Rev Gastroenterol Hepatol., 11(1): 19-32, 2017

  7. Wygrecka M, Kosanovic D, Zakrzewicz D, Hess R, Henneke I, Didiasova M, Wujak L, Baal N, Hackstein H, Reppe K, Müller-Redetzky HC, Witzenrath M, de Maat S, Maas C, Nolte MV, Panousis C, Ralph T. Schermuly RT, Schaefer L, and Markart P. C1 esterase inhibitor protects against histone-mediated lung injury. Am J Respir Crit Care Med., 196: 186-199, 2017

  8. Friedländer F, Bohmann F, Brunkhorst M, Chae JH, Devraj K, Köhler Y, Kraft P, Kuhn H, Lucaciu A, Luger S, Pfeilschifter W, Sadler R, Liesz A, Scholtyschik K, Stolz L, Vutukuri R, and Brunkhorst R. Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach. J Cereb Blood Flow Metab., 37(8): 3015-3026, 2017

  9. Frölich S, Slattery P, Thomas D, Goren I, Ferreiros N, Jensen BL, and Nüsing RM. Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation. Kidney Int., 91: 818-829, 2017

  10. Bachmann M, Meissner C, Pfeilschifter J, and Mühl, H. Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. Biofactors, 43(2): 283-292, 2017

  11. Badawi A, Hehlgans S, Pfeilschifter J, Rödel F and Eberhardt W. Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. Cancer Lett., 393: 103-112, 2017

  12. Ball AK, Beilstein K, Wittmann S, Sürün D, Saul M, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber S. Characterization and cellular localization of human 5lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12. Biochim Biophys Acta 1862: 561-571, 2017

  13. Slattery P, Frölich S, Goren I, and Rolf Nüsing. Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice. American Journal of Physiology - Renal Physiology, 312(6):F1044-F1055, 2017

  14. Hsieh LTH, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, and Schaefer L. Biglycan- and sphingosine kinase1-signaling crosstalk regulates the synthesis of macrophage chemoattractants. Int J Mol Sci , 18, 595; doi:10.3390/ijms18030595, 2017

  15. Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dötsch V, and Rajalingam K. Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2. EMBO Rep., 18(5):733-744, 2017

  16. Nastase MV, Janicova A, Wygrecka M, and Schaefer L. Signaling at the crossroads: Matrix-derived proteoglycan- and reactive oxygen species signaling. Antioxid Redox Signal, 27: 855-873, 2017

  17. Wujak L, Hesse C, Sewald K, Jonigk D, Braubach P, Warnecke G, Fieguth HG, Braun A, Lochnit G, Markart P, Schaefer L, and Wygrecka M. FXII promotes proteolytic processing of the LRP1 ectodomain. Biochim Biophys Acta Gen Subject 1861: 2088-2098, 2017

  18. Chichelnitskiy E, Himmelseher B, Bachmann M, Pfeilschifter J, and Mühl H. Hypothermia promotes IL-22 expression and fine-tunes its biological activity. Front Immunol.8: 742, 2017

  19. Bachmann M, Waibler Z, Pleli T, Pfeilschifter J and Mühl H. Type I interferon supports inducible nitric oxide synthase in murine hepatoma cells and hepatocytes and during experimental acetaminophen-induced liver damage. Front Immunol. 2017 Jul 31;8:890. doi: 10.3389/fimmu.2017.00890. eCollection 2017.

  20. Koch A, Grammatikos G, Trautmann S, Schreiber Y, Thomas D, Bruns F, Pfeilschifter J, Badenhoop K, and Penna-Martinez M. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. Int J Mol Sci. 18(7), pii: E1532. doi: 10.3390/ijms18071532. PubMed PMID: 28714882, 2017

  21. Hinrichsen I, Weßbecher IM, Huhn M, Passmann S, Zeuzem S, Plotz G, Biondi RM, and Brieger A. Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2. Mol Carcinog., 56(12): 2663-2668, 2017

  22. Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth H-G, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler W, Markart P, and Wygrecka M. Coagulation factor XII regulates inflammatory responses in human lungs. Thromb Haemost., 117(10): 1896-1907, 2017

  23. Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, and Pfeilschifter J. Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction.Am J Pathol, 187: 2413-2429, 2017

  24. Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, and Meyer Zu Heringdorf D. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep., 7: 43575. doi: 10.1038/srep43575, 2017

  25. Richter C, Herrero San Juan M, Weigmann B, Bergis D, Dauber K, Muders MH, Baretton GB, Pfeilschifter JM, Bonig H, Brenner S, and Radeke HH. Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer. Front Immunol., 8:44. doi: 10.3389/fimmu.2017.00044. eCollection 2017, 2017

  26. Aglan A, Longen S, Dehne N, Köhler Y, Hassan M, Beck M, Tredup C, Boosen M, Hsieh TL, Schaefer L, Beck KF, and Pfeilschifter J. Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis. J Mol Med (Berl)., 95(3):257-271, 2017

  27. Bonvin P, Gueneau F, Buatois V, Charreton-Galby M, Lasch S, Messmer M, Christen U, Luster AD, Johnson Z, Ferlin W, Kosco-Vilbois M, Proudfoot A, and Fischer N. Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES. J Biol Chem., 10; 292(10): 4185-4197, 2017

  28. Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, and Lang KS. Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells. Front Immunol., 8: 113. doi: 10.3389/fimmu.2017.00113. eCollection 2017, 2017

  29. Oertel S, Scholich K, Weigert A, Thomas D, Schmetzer J, Trautmann S, Wegner MS, Radeke HH, Filmann N, Brüne B, Geisslinger G, Tegeder I, and Grösch S. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Sci., 74(16): 3039-3055, 2017

  30. Schmidt K, Herrero San Juan M, Trautmann S, Berninger L, Schwiebs A, Ottenlinger F, Thomas D, Zau