Publikationen 2019

  1. Zucker M, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M. LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension. Biochim Biophys Acta - Molecular Basis of Disease in press

  2. Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LTH, Brandts C, Fulda S, Wygrecka M, and Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol., 77, 4-22, 2019

  3. Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Muench C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L: Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury.Kidney Int., 95: 540-562, 2019

  4. Christen U and Hintermann E. Pathogens and autoimmune hepatitis. Clin Exp Immunol., 195(1): 35-51, 2019

  5. Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J. 2019 Feb;33(2):1711-1726.

  6. Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids, 1864(3): 304-311, 2019

  7. Roedig H, Nastase MV, Wygrecka M, Schaefer L. Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J. 2019 Feb 18. doi: 10.1111/febs.14791. [Epub ahead of print] PubMed PMID: 30776184.

  8. Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene. doi: 10.1038/s41388-019-0758-x. [Epub ahead of print] PubMed PMID: 30816345,2019 (in press)

  9. Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S. Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. Nitric Oxide,87: 31-42, 2019

  10. Büttner S, Koch A, Pfeilschifter J. Diuretic Therapy. Dtsch Med Wochenschr., 144(6): 387-392, German, 2019

  11. Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M. Lipids - two sites of the same coin in lung fibrosis. Cell Signal, 2019 (in press)

Publikationen 2018

  1. Nastase MV, Janicova A, Roedig H, Hsieh LTH, Wygrecka M, and Schaefer L. Small leucine-rich proteoglycans in renal inflammation: two sides of the coin. J Histochem Cytochem, 66(4): 261-272, 2018

  2. Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, and Schaefer L. Danger associated molecular patterns from the extracellular matrix provide temporal control of innate immunity. J Histochem Cytochem, 66(4): 213–227, 2018

  3. Wujak L, Böttcher R, Pak O, Frey H, El Agha E, Chen Y, Schmitt S, Bellusci S, Schaefer L, Weissmann N, Fässler R, and Wygrecka M. Low Density Lipoprotein Receptor-related Protein 1 Couples β1 Integrin Activation to Degradation.Cell Mol Life Sci, 75: 1671-1685, 2018

  4. Hermann A, Wennmann DO, Gromnitza S, Edeling M, van Marck V, Sudol M, Schaefer L, Duning K, Weide T, Pavenstädt H, and Kremerskother J. WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hepatology, 67(4): 1546-1559, 2018

  5. Hardt S, Valek L, Zeng-Brouwers J, Wilken-Schmitz A, Schaefer L, and Tegeder I. Nephrogenic diabetes insipidus in aged progranulin deficient mice. Aging Dis. 9(5): 817-830, 2018

  6. Vutukuri R, Brunkhorst R, Kestner RI, Hansen L, Ferreiros Bouzas N, Pfeilschifter J, Devraj K, and Pfeilschifter W.Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption. J Neurochem., 144(2): 172-185, 2018

  7. Schwiebs A and Radeke H. Immunopharmacological activity of betulin in inflammation-associated carcinogenesis.Anticancer Agents Med Chem. 18(5): 645-651, 2018

  8. Wujak L, Schniedera J, Schaefer L, and Wygrecka M. LRP1: a chameleon receptor of lung inflammation and repair.Matrix Biol., 68-69: 366-381, 2018

  9. Imre G and Rajalingam K. Apoptosis Inhibitor 5: Role in the inhibition of caspase-2. Cell Cycle. 17(4): 397-398, 2018

  10. Nastase MV, Zeng-Brouwers J, Wygrecka M, and Schaefer L. Targeting renal fibrosis: mechanisms and drug delivery systems. Adv Drug Deliv Rev, 129: 295-307, 2018

  11. Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Hattenbach LO, Pfeilschifter J, and Pfeilschifter W. Sphingosine kinase 2 modulates retinal neovascularization Invest Ophthalmol Vis Sci., 59(2): 653-661, 2018

  12. Bachmann M, Pfeilschifter J, and Mühl H. A prominent role of IL-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation. Front Immunol, 9: 161. doi: 10.3389/fimmu.2018.00161. eCollection 2018

  13. Goren I, Christen U, Pfeilschifter J, and Stefan Frank. A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds. Nitric Oxide, 74:23-31, 2018

  14. Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M, and Schaefer L.Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biol 68-69: 293-317, 2018

  15. Bachmann M, Pfeilschifter J, and Mühl H. Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells. BBA-GENE REGUL MECH, 1861(3): 191-199, 2018

  16. Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, and Wygrecka M. Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta - Molecular Basis of Disease, 1864(5 Pt A): 1816-1827, 2018

  17. Wagner J, Chavakis E, Rogg E-M, Muhly-Reinholz M, Glaser SF, Guenther S, John D, Bonini F, Zeiher A, Schaefer L, Hannocks M-J, Boon RA, and Dimmeler S. A switch in laminin β2 to laminin β1 isoforms during aging enhances endothelial-mesenchymal transition. Arterioscler Thromb Vasc Biol., 38: 1170-1177, 2018

  18. Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, and Eberhardt W. Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells. Oncotarget, 9(26): 18367-18385, 2018

  19. Didiasova M, Schaefer L, and Wygrecka M. Targeting GLI transcription factors in cancer.  Molecules, 23(5). pii: E1003. doi: 10.3390/molecules23051003, 2018

  20. Schaefer L. Decoding fibrosis: Mechanisms and translational aspects. Matrix Biol 68-69: 1-7, 2018

  21. Brunkhorst R, Pfeilschifter W, Patyna S, Büttner S, Eckes T, Trautmann S, Thomas D, Pfeilschifter J, and Koch A.Preanalytical Biases in the Measurement of Human Blood Sphingolipids. Int J Mol Sci., 19(5), 2018

  22. Patyna S, Eckes T, Büttner S, Pfeilschifter J, and Koch A. Sphingosine 1-phosphate in renal diseases: Molecular mechanisms and clinical relevance. Nieren- und Hochdruckkrankheiten, Jahrgang 47, März (137-141), 2018

  23. Huwiler A and Pfeilschifter J. Sphingolipid signaling in renal fibrosis. Matrix Biol., 68-69, 230-247, 2018

  24. Christen U, Hintermann E. Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease? Front Immunol. 2018 Feb 16;9:163. doi: 10.3389/fimmu.2018.00163. eCollection 2018. Review.

  25. Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, and Christen U. Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun., 91: 83-96, 2018

  26. Christen U. Animal models of autoimmune hepatitis. Biochim Biophys Acta. 2018 May 29. pii: S0925-4439(18)30187-X. doi: 10.1016/j.bbadis.2018.05.017. [Epub ahead of print]

  27. Kwapiszewska G, Gungl A, Wilhelm J; Marsh L, Thekkekara Puthenparampil H; Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, and Wygrecka M. Transcriptome profiling reveals the complexity of pirfenidone effects in IPF.  Eur Respir J, 52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018, 2018

  28. Rogg EM, Abplanalp WT, Bischof C, John D, Schulz MH, Krishnan J, Fischer A, Poluzzi C, Schaefer L, Bonauer A, Zeiher AM, and Dimmeler S. Analysis of cell type-specific effects of miR-92a provides novel insights into target regulation and mechanism of action. Circulation, 138:2545-2558, 2018

  29. Didiasova M, Wujak M, Schaefer L, Wygrecka M: Cellular effects of coagulation factor XII. Cell Signal, 51: 257-265. 2018

  30. Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol. 2018 Oct 15. pii: S0960-0760(18)30349-2. doi: 10.1016/j.jsbmb.2018.10.005. [Epub ahead of print] PubMed PMID: 30336275.

  31. Beyer S, Schwalm S, Pfeilschifter J, and Huwiler A. Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis. Cell Physiol Biochem., 47: 2522-2533, 2018

  32. Eberhardt W, Nasrullah U, and Pfeilschifter J. Activation of renal profibrotic TGFbeta controlled signaling cascades by calcineurin and mTOR inhibitors. Cell Signal, 52: 1-11, 2018

  33. Luger S, Schwebler A, Vutukuri R, Bouzas NF, Labocha S, Schreiber Y, Brunkhorst R, Steinmetz H, Pfeilschifter J, Pfeilschifter W. Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke. Ther Adv Neurol Disord., 11:1756286418769830. doi: 10.1177/1756286418769830, 2018

  34. Danciu C, Zupko I, Bor A, Schwiebs A, Radeke H, Hancianu M, Cioanca O, Alexa E, Oprean C, Bojin F, Soica C, Paunescu V, and Dehelean CA. Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells.Int J Mol Sci., 19(11). pii: E3624, 2018

  35. Blanchard O, Stepanovska B, Starck M, Erhardt M, Römer I, Meyer Zu Heringdorf D, Pfeilschifter J, Zangemeister-Wittke U, Huwiler A. Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells. Int J Mol Sci., 19(5). pii: E1498, 2018

  36. Bruno G, Cencetti F, Bernacchioni C, Donati C, Blankenbach KV, Thomas D, Meyer Zu Heringdorf D, Bruni P. Bradykinin mediates myogenic differentiation in murine myoblasts through the involvement of SK1/Spns2/S1P(2) axis. Cell Signal., 45: 110-121, 2018

  37. Josipovic I, Pflüger B, Fork C, Vasconez AE, Oo JA, Hitzel J, Seredinski S, Gamen E, Heringdorf DMZ, Chen W, Looso M, Pullamsetti SS, Brandes RP, Leisegang MS. Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell  function. J Mol Cell Cardiol., 116: 57-68, 2018

  38. Pleli T, Mondorf A, Ferreiros N, Thomas D, Dvorak K, Biondi RM, Heringdorf DMZ, Zeuzem S, Geisslinger G, Zimmermann H, Waidmann O, Piiper A. Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors. Cell Physiol Biochem., 45(6): 2516-2528, 2018

  39. Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D. Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses. Biochim Biophys Acta Mol Cell Biol Lipids., 1863(4): 433-446, 2018

  40. Moll F, Walter M, Rezende F, Helfinger V, Vasconez E, De Oliveira T, Greten FR, Olesch C, Weigert A, Radeke HH, Schröder K. NoxO1 Controls Proliferation of Colon Epithelial Cells. Front Immunol., 9:973. doi: 10.3389/fimmu.2018.00973. eCollection 2018, 2018 

Publikationen 2017

  1. Goren I, Lee SY, Maucher D, Nüsing R, Schlich T, Pfeilschifter J, and Frank S. Inhibition of cyclooxygenase-1 and -2 activity in keratinocytes inhibits PGE2 formation and impairs VEGF release and neovascularization in skin wounds.Int Wound J., 14: 53-63, 2017

  2. Frey H, Moreth K, Hsieh LTH, Zeng-Brouwers J, Rathkolb B, Fuchs H, Gailus-Durner V, Iozzo RV, Hrabě de Angelis M, and Schaefer L. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J., 34(3): 393-404, 2017

  3. Schaefer L, Tredup C, Gubbiotti M, and Iozzo RV. Proteoglycan neofunctions: Regulation of inflammation and autophagy in cancer biology. FEBS J 284: 10-26, 2017

  4. Bender C, Christen S, Scholich K, Bayer M, Pfeilschifter JM, Hintermann E, and Christen U. Islet-expressed CXCL10 Promotes Autoimmune Destruction of Islet Iso-Grafts in Mice with Type 1 Diabetes. Diabetes. 66(1): 113-126, 2017

  5. Didiasova M, Singh R, Kwapiszewska G, Wujak L, Zakrzewicz D, Markart P, Seeger W, Schaefer L, Lauth M, and Wygrecka M. Pirfenidone exerts anti-fibrotic effects through a direct inhibition of GLI transcription factors. FASEB J 31: 1916-1928, 2017

  6. Martin J, Radeke HH, Dignass A and Stein J. Curent evaluation and management of anaemia in patients with inflammatory bowel disease. Expert Rev Gastroenterol Hepatol., 11(1): 19-32, 2017

  7. Wygrecka M, Kosanovic D, Zakrzewicz D, Hess R, Henneke I, Didiasova M, Wujak L, Baal N, Hackstein H, Reppe K, Müller-Redetzky HC, Witzenrath M, de Maat S, Maas C, Nolte MV, Panousis C, Ralph T. Schermuly RT, Schaefer L, and Markart P. C1 esterase inhibitor protects against histone-mediated lung injury. Am J Respir Crit Care Med., 196: 186-199, 2017

  8. Friedländer F, Bohmann F, Brunkhorst M, Chae JH, Devraj K, Köhler Y, Kraft P, Kuhn H, Lucaciu A, Luger S, Pfeilschifter W, Sadler R, Liesz A, Scholtyschik K, Stolz L, Vutukuri R, and Brunkhorst R. Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach. J Cereb Blood Flow Metab., 37(8): 3015-3026, 2017

  9. Frölich S, Slattery P, Thomas D, Goren I, Ferreiros N, Jensen BL, and Nüsing RM. Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation. Kidney Int., 91: 818-829, 2017

  10. Bachmann M, Meissner C, Pfeilschifter J, and Mühl, H. Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. Biofactors, 43(2): 283-292, 2017

  11. Badawi A, Hehlgans S, Pfeilschifter J, Rödel F and Eberhardt W. Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. Cancer Lett., 393: 103-112, 2017

  12. Ball AK, Beilstein K, Wittmann S, Sürün D, Saul M, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber S. Characterization and cellular localization of human 5lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12. Biochim Biophys Acta 1862: 561-571, 2017

  13. Slattery P, Frölich S, Goren I, and Rolf Nüsing. Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice. American Journal of Physiology - Renal Physiology, 312(6):F1044-F1055, 2017

  14. Hsieh LTH, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, and Schaefer L. Biglycan- and sphingosine kinase1-signaling crosstalk regulates the synthesis of macrophage chemoattractants. Int J Mol Sci , 18, 595; doi:10.3390/ijms18030595, 2017

  15. Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dötsch V, and Rajalingam K. Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2. EMBO Rep., 18(5):733-744, 2017

  16. Nastase MV, Janicova A, Wygrecka M, and Schaefer L. Signaling at the crossroads: Matrix-derived proteoglycan- and reactive oxygen species signaling. Antioxid Redox Signal, 27: 855-873, 2017

  17. Wujak L, Hesse C, Sewald K, Jonigk D, Braubach P, Warnecke G, Fieguth HG, Braun A, Lochnit G, Markart P, Schaefer L, and Wygrecka M. FXII promotes proteolytic processing of the LRP1 ectodomain. Biochim Biophys Acta Gen Subject 1861: 2088-2098, 2017

  18. Chichelnitskiy E, Himmelseher B, Bachmann M, Pfeilschifter J, and Mühl H. Hypothermia promotes IL-22 expression and fine-tunes its biological activity. Front Immunol.8: 742, 2017

  19. Bachmann M, Waibler Z, Pleli T, Pfeilschifter J and Mühl H. Type I interferon supports inducible nitric oxide synthase in murine hepatoma cells and hepatocytes and during experimental acetaminophen-induced liver damage. Front Immunol. 2017 Jul 31;8:890. doi: 10.3389/fimmu.2017.00890. eCollection 2017.

  20. Koch A, Grammatikos G, Trautmann S, Schreiber Y, Thomas D, Bruns F, Pfeilschifter J, Badenhoop K, and Penna-Martinez M. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. Int J Mol Sci. 18(7), pii: E1532. doi: 10.3390/ijms18071532. PubMed PMID: 28714882, 2017

  21. Hinrichsen I, Weßbecher IM, Huhn M, Passmann S, Zeuzem S, Plotz G, Biondi RM, and Brieger A. Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2. Mol Carcinog., 56(12): 2663-2668, 2017

  22. Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth H-G, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler W, Markart P, and Wygrecka M. Coagulation factor XII regulates inflammatory responses in human lungs. Thromb Haemost., 117(10): 1896-1907, 2017

  23. Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, and Pfeilschifter J. Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction.Am J Pathol, 187: 2413-2429, 2017

  24. Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, and Meyer Zu Heringdorf D. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep., 7: 43575. doi: 10.1038/srep43575, 2017

  25. Richter C, Herrero San Juan M, Weigmann B, Bergis D, Dauber K, Muders MH, Baretton GB, Pfeilschifter JM, Bonig H, Brenner S, and Radeke HH. Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer. Front Immunol., 8:44. doi: 10.3389/fimmu.2017.00044. eCollection 2017, 2017

  26. Aglan A, Longen S, Dehne N, Köhler Y, Hassan M, Beck M, Tredup C, Boosen M, Hsieh TL, Schaefer L, Beck KF, and Pfeilschifter J. Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis. J Mol Med (Berl)., 95(3):257-271, 2017

  27. Bonvin P, Gueneau F, Buatois V, Charreton-Galby M, Lasch S, Messmer M, Christen U, Luster AD, Johnson Z, Ferlin W, Kosco-Vilbois M, Proudfoot A, and Fischer N. Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES. J Biol Chem., 10; 292(10): 4185-4197, 2017

  28. Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, and Lang KS. Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells. Front Immunol., 8: 113. doi: 10.3389/fimmu.2017.00113. eCollection 2017, 2017

  29. Oertel S, Scholich K, Weigert A, Thomas D, Schmetzer J, Trautmann S, Wegner MS, Radeke HH, Filmann N, Brüne B, Geisslinger G, Tegeder I, and Grösch S. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Sci., 74(16): 3039-3055, 2017

  30. Schmidt K, Herrero San Juan M, Trautmann S, Berninger L, Schwiebs A, Ottenlinger F, Thomas D, Zaucke F, Pfeilschifter JM, and Radeke HH. Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study.Front Immunol. 2017 Sep 29;8:1242. doi: 10.3389/fimmu.2017.01242. eCollection 2017.

  31. Stein J, Aksan A, Farrag K, Dignass A, and Radeke HH. Management of inflammatory bowel disease-related anemia and iron deficiency with specific reference to the role of intravenous iron in current practice. Expert Opin Pharmacother., 18(16): 1721-1737, 2017

  32. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Letter: the importance of dosing and baseline haemoglobin when establishing the relative efficacy of intravenous iron therapies-authors' reply. Aliment Pharmacol Ther., 46(7): 705-706, 2017

  33. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Letter: inconsistency in reporting of hypophosphataemia after intravenous iron-authors' reply. Aliment Pharmacol Ther., 46(6): 643-644, 2017

  34. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Editorial: which iron preparation for patients with IBD? Authors' reply. Aliment Pharmacol Ther., 46(2): 195-196, 2017

  35. Aksan A, Işık H, Radeke HH, Dignass A, and Stein J. Systematic review with network meta-analysis: comparative efficacy and tolerability of different intravenous iron formulations for the treatment of iron deficiency anaemia in patients with inflammatory bowel disease. Aliment Pharmacol Ther., 45(10): 1303-1318, 2017

  36. Schwiebs A, Thomas D, Kleuser B, Pfeilschifter JM, and Radeke HH. Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells. Mediaters Inflamm., 2017:5187368. doi: 10.1155/2017/5187368. Epub 2017 Dec 11, 2017

Publikationen 2016

  1. Poluzzi C, Iozzo RV, and Schaefer L. Endostatin and endorepellin: a common route of action for similar angiostatic cancer avengers. Adv Drug Deliv Rev 97: 156-173, 2016.

  2. Neill T, Schaefer L, and Iozzo RV. Decorin as a multivalent therapeutic agent against cancer. Adv Drug Deliv Rev 97: 174-185, 2016.

  3. Hsieh LT, Frey H, Nastase MV, Tredup C, Hoffmann A, Poluzzi C, Zeng-Brouwers J, Manon-Jensen T, Schröder K, Brandes RP, Iozzo RV, and Schaefer L. Bimodal role of NADPH Oxidases in the regulation of biglycan-triggered IL-1β synthesis. Matrix Biol 49: 61-81, 2016

  4. Berner A, Bachmann M, Bender C, Pfeilschifter J, Christen U and Mühl H. Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes. Front Pharmacol., 6: 317, 2016

  5. Ottenlinger F, Schwiebs A, Pfarr K, Wagner A, Grüner S, Mayer C, Pfeilschifter JM, Radeke HH. Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. Eur J Immunol., 46(4): 941-951, 2016.

  6. Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, and Lang KS. Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation. J Autoimmun., 67: 82-89, 2016.

  7. Bergis D, Kassis V, and Radeke HH. High plasma sST2 levels in gastric cancer and their association with metastatic disease. Cancer Biomarkers 16: 117–125, 2016

  8. Klionsky DJ, …. Schaefer, L,…. and Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222, 2016.

  9. Schaefer L and Reinhardt DP Extracellular matrix: Therapeutic tools and targets in cancer treatment. Adv Drug Deliv Rev 97: 1-3, 2016

  10. Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock L, and Fischer JW. Loss of biglycan enhances thrombin generation in ApoE-deficient mice: Implications for inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 36: e41-50, 2016

  11. Mühl, H. STAT3, a key parameter of cytokine-driven tissue protection during sterile inflammation – the case of experimental acetaminophen (paracetamol)-induced liver damage. Front Immunol. 7: 163, 2016

  12. Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, and Schaefer L. An essential role for SHARPIN in the regulation of caspase 1 activity in sepsis. Am J Pathol 186: 1206-1220, 2016

  13. Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, and Becker-Pauly C. Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains. Biol Chem., 397(9): 857-869, 2016

  14. Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, and Thiemermann C. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis.Sci Rep. 6:27594, 2016

  15. Grammatikos G, Schoell N, Ferreirós N, Bon D, Herrmann E, Farnik H, Köberle V, Piiper A, Zeuzem S, Kronenberger B, Waidmann O, and Pfeilschifter J. Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. Oncotarget, 7(14): 18095-18105, 2016

  16. Grammatikos G, Dietz J, Ferreiros N, Koch A, Dultz G, Bon D, Karakasiliotis I, Lutz T, Knecht G, Gute P, Herrmann E, Zeuzem S, Mavromara, Sarrazin C, and Pfeilschifter J. Persistence of HCV in acutely-infected patients depletes C24-ceramide and upregulates sphingosine and sphinganine serum levels. Int J Mol Sci, 17: 922, 2016

  17. Barallobre-Barreiro J, Gupta S, Zoccaratto A, Fava M, Yin X, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah A, Jahangiri M, Schaefer L, Fischer J, Iozzo RV, Viner R, Kichler A, Thum T, Heineke J, and Mayr M. Glypoproteomix reveals decorin fragments with anti-myostatin activity in human atrial fibrillation. Circulation, 134: 817-832, 2016

  18. Imeri F, Schwalm S, Lyck R, Zivkovic A, Stark H, Engelhardt B, Pfeilschifter J, and Huwiler A. Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. Neuropharmacology, 105: 341-350, 2016

  19. Müller P, Messmer M, Bayer M, Pfeilschifter JM, Hintermann E, and Christen U. Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model. J Autoimmun., 69: 51-58, 2016

  20. Hintermann E, Bayer M, Ehser J, Aurrand-Lions M, Pfeilschifter JM, Imhof BA, and Christen U. Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis. Cell Adh Migr., 10(4): 419-433, 2016

  21. Schwiebs A, Friesen O, Katzy E, Ferreirós N, Pfeilschifter JM, and Radeke HH. Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1. Front Pharmacol., 7: 94, 2016

  22. Longen S, Richter F, Köhler Y, Wittig I, Beck KF, and Pfeilschifter J. Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells. Sci Rep., 6: 29808, 2016

  23. Blankenbach KV, Schwalm S, Pfeilschifter J, and Meyer Zu Heringdorf D. Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks. Front Pharmacol., 7: 167, 2016

  24. Longen S, Beck KF, and Pfeilschifter J. H2S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases. Pharmacol Res., 111: 642-651, 2016

  25. Eberhardt W, Badawi A, Biyanee A, and Pfeilschifter J. Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons.