Publikationen der letzten 5 Jahre

Blood-Brain Barrier Breakdown Determines Differential Therapeutic Outcome in Genetically Diverse Forms of Medulloblastoma.
Guerit S, Liebner S.
Cancer Cell. 2016 Apr 11;29(4):427-9. 

Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.
Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y.
Acta Neuropathol. 2016 May;131(5):753-73. 

BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Devraj K, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S.
J Cereb Blood Flow Metab. 2016 Jul;36(7):1281-94. 

Multiple Antenatal Dexamethasone Treatment Alters Brain Vessel Differentiation in Newborn Mouse Pups.
Neuhaus W, Schlundt M, Fehrholz M, Ehrke A, Kunzmann S, Liebner S, Speer CP, Förster CY.
PLoS One. 2015 Aug 14;10(8):e0136221. 

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.
Zinke J, Schneider FT, Harter PN, Thom S, Ziegler N, Toftgård R, Plate KH, Liebner S.
Mol Cancer. 2015 Feb 3;14:17. 

Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas.
Harter PN, Baumgarten P, Zinke J, Schilling K, Baader S, Hartmetz AK, Schittenhelm J, Beschorner R, Liebner S, Schulte D, Plate KH, Gutwein P, Korshunov A, Pfister SM, Jones DT, Doberstein K, Mittelbronn M.
Neuropathol Appl Neurobiol. 2015 Feb;41(2):165-79. 

Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.
Feng Y, Gross S, Wolf NM, Butenschön VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes HP, Wieland T.
Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2292-300. 

Sonic hedgehog causes mural cells to jump 'n' run.
Liebner S.
Blood. 2014 Apr 10;123(15):2285-6.

Novel insights into the development and maintenance of the blood-brain barrier.
Engelhardt B, Liebner S.
Cell Tissue Res. 2014 Mar;355(3):687-99. Epub 2014 Mar 4.

EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells.
Liu H, Devraj K, Möller K, Liebner S, Hecker M, Korff T.
Thromb Haemost. 2014 Jul 3;112(1):151-63. Epub 2014 Feb 13.

In vitro models of the blood-brain barrier.
Czupalla CJ, Liebner S, Devraj K.
Methods Mol Biol. 2014;1135:415-37. 

Analysis of angiogenesis in the developing mouse central nervous system.
Ziegler N, Plate KH, Liebner S.
Methods Mol Biol. 2014;1135:55-68.

The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells.
Artus C, Glacial F, Ganeshamoorthy K, Ziegler N, Godet M, Guilbert T, Liebner S, Couraud PO.
J Cereb Blood Flow Metab. 2014 Mar;34(3):433-40. Epub 2013 Dec 18.

Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis.
Paganetti P, Antoniello K, Devraj K, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, Muhs A.
J Alzheimers Dis. 2014;38(4):767-86. 

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro.
Paolinelli R, Corada M, Ferrarini L, Devraj K, Artus C, Czupalla CJ, Rudini N, Maddaluno L, Papa E, Engelhardt B, Couraud PO, Liebner S, Dejana E.
PLoS One. 2013 Aug 5;8(8):e70233. Print 2013.

Wnt signaling in the vasculature.
Reis M, Liebner S.
Exp Cell Res. 2013 May 15;319(9):1317-23. Epub 2013 Jan 3.

Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus.
Wyss L, Schäfer J, Liebner S, Mittelbronn M, Deutsch U, Enzmann G, Adams RH, Aurrand-Lions M, Plate KH, Imhof BA, Engelhardt B.
PLoS One. 2012;7(9):e45619.  Epub 2012 Sep 18.

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.
Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S.
J Exp Med. 2012 Aug 27;209(9):1611-27. Epub 2012 Aug 20.

Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols.
Frömel T, Jungblut B, Hu J, Trouvain C, Barbosa-Sicard E, Popp R, Liebner S, Dimmeler S, Hammock BD, Fleming I.
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9995-10000. Epub 2012 Jun 4.

Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow.
Assmus B, Iwasaki M, Schächinger V, Roexe T, Koyanagi M, Iekushi K, Xu Q, Tonn T, Seifried E, Liebner S, Kranert WT, Grünwald F, Dimmeler S, Zeiher AM.
Eur Heart J. 2012 Aug;33(15):1911-9. Epub 2011 Dec 15.

Caveolin-1 opens endothelial cell junctions by targeting catenins.
Kronstein R, Seebach J, Grossklaus S, Minten C, Engelhardt B, Drab M, Liebner S, Arsenijevic Y, Taha AA, Afanasieva T, Schnittler HJ.
Cardiovasc Res. 2012 Jan 1;93(1):130-40. Epub 2011 Sep 29.

Current concepts of blood-brain barrier development.
Liebner S, Czupalla CJ, Wolburg H.
Int J Dev Biol. 2011;55(4-5):467-76. Review.

NADPH oxidase Nox1 contributes to ischemic injury