Mesenchymal stroma cells

for treatment of steroid-refractory acute GvHD

Acute graft-versus-host disease is still a major complication after allogeneic stem cell transplantation, especially when conventional therapy options fail. In steroid-refractory acute graft-versus-host disease, mesenchymal stromal cells and their immunomodulatory properties have shown to be an effective treatment option.

In our center, we have developed a method of generating standardized MSC preparations from pooled bone marrow mononuclear cells of 8 different donors, which are characterized by a consistent and reproducible effectiveness